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The statistics on the rising rates of skin cancer are alarming. According to the Skin Cancer Foundation, each year over 5. Telehealth is the delivery of health care remotely via telecommunication tools. Its aim is to increase access to care, especially for patients with chronic diseases such as cancer and for populations for whom care is not always available. With the growing availability of broadband and po In October , ASCO launched the Health Policy Fellowship program to help the next generation of oncologists with an interest in health policy to develop the skills and experience necessary to achieve their goals and shape cancer care policy in an increasingly complicated and diverse care delivery Although initiation of palliative care from the time of cancer diagnosis produces optimal outcomes for patients, this strategy is often not practiced.

A recent Canadian study conducted in patients with advanced cancer and their caregivers examined the opinions of patients with advanced c Alfred Yung, MD, has wanted a career in medicine since he was a high-school student and has spent nearly 4 decades fulfilling that dream, specifically in the research and treatment of one of the deadliest cancers, malignant brain tumor, especially glioblastoma multiforme, the most common brai Despite the routine use of HER2 blockade in early HER2-positive breast cancer, clinicians can always benefit from a refresher on key treatment considerations.

Clinical pearls and controversial issues were the topic of a presentation at the 14th Annual School of Breast Oncology at Emory U Supportive Care. Launching a new cancer journal is a risky and arduous endeavor, especially for a specialty publication in resource-challenged countries in the developing world. To succeed, a specialty journal must publish articles from established clinical researchers that quickly garner funding and captivate its i Wit tells the story of an accomplished Allogeneic hematopoietic stem cell transplantation is the only potentially curative treatment for myelofibrosis.

The ASCO Post asked an expert in this field, Ayalew Tefferi, MD, how and when he uses stem cell transplant in myelofibrosis, which is a topic he outlined in greater detail in Earlier this year, Sean Parker, the cofounder of the music streaming service Napster and an early president of Facebook, joined a growing list of entrepreneurs who are committing large portions of their wealth to funding cancer research. In April, Mr. Lung Cancer Cost of Care. Over the past few years, the term value-based cancer care has become integrated into the vernacular of the oncology community.

Value is a subjective term, which is defined largely by its clinical setting. However, value in cancer care is evaluated by the multiple stakeholders involved in It should not come as a surprise to anyone who has read Dr. The Quality Payment Progra Head and Neck Cancer. The treatment of cancer of the larynx has changed dramatically in recent years. With organ preservation now possible in many cases, it is more important than ever for patients to receive guidance from every corner of the field. Whole-brain radiotherapy has been the traditional treatment modality, but stereotact Today, it is grabbing headlines for becoming an important assistant in cancer care.

Able to read and understand millions of pages of text within seconds, Watson caught the att Gynecologic Cancers. Cervical cancer incidence and mortality rates—perhaps more than any other chronic disease—shine a grim spotlight on global disparities of care. It is one of the most preventable of human malignancies, yet it is the leading cause of cancer deaths in women around the world.

It kills , Now, another A recent report regarding pembrolizumab Keytruda for advanced Merkel cell carcinoma ushered in a more optimistic era in the treatment of this rare but often lethal skin cancer. Sumanta K. Pal, MD, has had a longer career in oncology than many other colleagues his age. Perhaps the reason for that may center on his starting college at the age 13 and medical school at the age of Today this internationally recognized leader in genitourinary cancers is Assistant Professor On August 25, , the U. The draft research plan for this topic was posted for public comment from May 26 to June 22, The Task Force On June 29, , Robert M.

The center was created in response to the overa The combination of more precise diagnostic tools and advances in surgery, chemotherapy, radiation therapy, and targeted therapy in the treatment of cancer has led to unprecedented numbers of cancer survivors in the United States—more than Issues in Oncology Global Cancer Care. Quyen D. In February, after serving for a year as the U.

Prior to his appointment at the FDA, Dr. Califf was the Donald The success of using social media to push forward causes for social good was a driving factor in the launch this past October of the Metastatic Breast Cancer Project MBC project , which aims to accelerate the understanding of what makes patients with metastatic breast cancer genetically unique. A nationwide project is enlisting patients with breast cancer to share their tumor samples and clinical information.

Launched in October , the Metastatic Breast Cancer MBC Project has enrolled more than 2, patients from all 50 states and is yielding information that will be shared with rese Just 6 months after President Barack Obama announced the establishment of a National Cancer Moonshot Initiative to accelerate the pace of research discoveries, improve patient access and care, and encourage data-sharing, dozens of new initiatives to accomplish those and other goals were rolled out a Cost of Care Issues in Oncology.

Geriatric Oncology. Although oncology has moved toward a personalized approach to care, medical decision-making within the context of multidisciplinary care has broad public health implications. With the advent of the Papanicolaou Pap test and population-based screening, along with the development of the human papillomavirus HPV vaccine, cervical cancer has become a largely preventable disease for many.

However, in India, cervical cancer is a leading cause of cancer mortality. To bet Mark A. Dickson, MD, has been fascinated by science and medicine since he was in high school. After graduating magna cum laude from Harvard University in , Dr. Once he decided on a On June 27, , Clifford A. Diagnosis and treatment of prostate cancer have been the source of heated debate for decades, most of which has centered on the clinical value of the prostate-specific antigen PSA test.

In , the U. Breast Cancer Global Cancer Care. It has been estimated that of the 15 million cancer Clifford A. As Physician-in-Chief, Dr. Yu will be responsible for working closely and collaboratively with phys Adults with cancer are at high risk for functional limitations that would negatively affect their quality of life. Occupational therapy offers a range of supportive services, with the specific goal of helping these patients engage in life as independently as possible.

To provide a better understan Survivorship Symptom Management. This past January, ASCO held its inaugural Cancer Survivorship Symposium, which brought together the fields of medical oncology and primary care to address the critical need for coordinated care for cancer survivors. The Middle East is a vast region comprised largely of developing nations with complicated sociopolitical challenges, violent internecine disputes, and deeply fragmented health-care systems.

Coley, MD, used bacterial toxins to goad the immune system into recognizing cancer cells as foreign to the body and mount an immune response to go after and kill them, the recognition of immunotherapy as a powerful anticancer therapy is finally being When Evelyn H. Gynecologic Cancers Issues in Oncology. Coleman, MD, and discussed the revolutionary potential of blood biomarkers, why enhanced recovery after surgery protocols is a significant innovat Although high-dose chemotherapy plus autologous transplantation has been a standard of care in the treatment of younger patients with newly diagnosed multiple myeloma, the advent of effective novel agents for the cancer over the past 15 years has raised the question of whether transplantation, with The advent of targeted therapies along with complex personalized treatment regimens has added many effective tools to the oncology armamentarium.

But progress has a price tag. Although the oncology community needs new drugs, there is growing concern that the price of many newer compounds is untenabl Symptom Management. Venous thromboembolic events are more prevalent in patients with cancer than in persons without it.


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Cancer is associated with a high rate of venous thromboembolism recurrence, bleeding, requirement for long-term anticoagulation, and reduced quality of life. Moreover, thrombosis is the second most co Although overall survival rates for patients with cancer continue to soar—with For adolescents and young adults with cancer—defined by the National Cancer Institute NCI as those in the to yea Bruce E. Johnson brings over 30 years of experience with ASCO to the position In , the American College of Surgeons encouraged the development of hospital-based registries, but for the most part, these efforts were clumsy, inaccessible card files of data.

Today, advanced microcomputer technology has increased the ability to not only collect and cull cancer data but also t There is also a substantial increase in the probability of developing ovarian cancers in wome Hematologic Malignancies Leukemia Issues in Oncology. Older patients with acute myeloid leukemia AML have high relapse rates after induction chemotherapy, low survival rates, and fewer treatment options compared with younger patients.

One of the options for both younger and older patients is hematopoietic cell transplantation, but relatively few olde Although the Evidence-based oncology practice is a systematic approach to problem solving for cancer care providers, characterized by the use of the best evidence currently available for clinical decision-making. Over the past several decades, the oncology community, led by its major organizations such as ASCO a A clinical dilemma that is receiving a great deal of attention in the oncology community is the undue financial burden some patients face during their treatment and into survivorship.

While much emphasis is put on methods to reduce and help patients navigate the complex payment system, little is kno In , when Bruce B. Then a student in Chinese and Asian studies and later an art history major, Dr. Miller would come to pursue a career specializing in palliative medicine after an acci Over the past few decades, the oncology community has incorporated new evidence-based therapies to address the psychosocial needs of patients with cancer, especially those with advanced disease.

Integrative Oncology Palliative Care.

Public Education about Cancer

Over the past couple of decades, the oncology community has made great strides in mediating the psychosocial needs of our patients. To reach a better understa The number of targeted therapies approved by the U. Food and Drug Administration FDA in the treatment of a variety of cancers, especially hematologic malignancies, continues to rise. In alone, 4 of the 10 new agents directed at discrete molecular targets approved by the FDA were for blood c Two years ago, Richard L.

The idea was to design a clinical s Improving the care of the imminently dying is an important issue in the oncology communit According to the National Cancer Institute NCI , about 70, adolescents and young adults—defined by the NCI as those in the to year-old range—are diagnosed with cancer each year in the United States, about six times the number of cases diagnosed in children aged 0 to Male breast cancer is an uncommon disease, although the incidence has increased over the past couple of decades.

Although it shares similarities with female breast cancer, some impor Pain Management. The statistics are staggering. Rural cancer patients have long had to adjust to difficult geographic and financial barriers to access high-quality cancer care. In , the T In a bold move to shed light on the ramifications of the ever-increasing cost of cancer drugs for patients with cancer and for the health-care system, prominent oncologists came together to write a commentary in Mayo Clinic Proceedings detailing their concerns.


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  8. Barnabas Hospital is located in the heart of Bronx, New York, and as such, it has a culturally diverse, largely poor, patient population. The backbone of successful palliative care services is the doctor-patient communication bonding process. However, many of the patients with late-stage cancer What first intrigued Fadlo R. Born in Boston, Massachusetts, in , Dr. Khuri was raised Despite enormous advances in modern medicine and the explosion of biomedical information over the past century, the way medical education is taught in the United States is stuck in a format that does not optimize learning, according to Charles Prober, MD, Senior Associate Dean for Medical Education For nearly a decade, Peter B.

    In , Dr. In addition to his new role, Dr. The stud Lung cancer doggedly remains the leading cause of cancer-related death in the United States. This grim mortality figure is due, in part, to a lack of early detection methods; more than half of all lung cancers have metastasized at the time of diagnosis. For decades, lung cancer advocates lobbied for Kravis Center for Molecular Oncology with the sole purpose of expediting the translation of novel molecular discoveries into clinical innovations to turn the goal of precision oncology care into a On April 1, , Douglas R.

    Three protagonists can share this clinical success story: prevention, early detection, and better therapies. To shed light on the current state of breast cancer research and therapy, Th Although the idea of using viruses to target cancer cells dates back more than years, technologic advances in the genetic engineering of viruses are now making it possible to safely test oncolytic virotherapy as a valid strategy against cancer cells. One type of genetically engineered virus that For over a decade, Patrick W. His early laboratory work using mouse models of bone cancer led to an und The son of actor Robert Alda, Mr.

    Alda began his acting career at the age of These changes are being precipitated by steeply rising health-care costs amid federa The Early Years You became Breast Cancer Pain Management. One persistent and potentially debilitating problem breast cancer patients suffer with is postoperative pain. Studies show that proper pain management is an essential component in the healing process, but undertreatment of pain symptoms remains an ongoing issue in the oncology community.

    Opioids, wh As the oncology community begins the slow and often difficult-to-define transition from volume to value in the delivery of cancer care, the relationship between the price and value of certain high-priced cancer drugs is getting more scrutiny. We generally correlate the efficacy of a new drug and its In January, ASCO released its report, Clinical Cancer Advances An Annual Report on Progress Against Cancer,1 which details research advances over the past decade that have led to longer survival and better quality of life for the more than half-a-million people diagnosed with cancer each year Gastrointestinal Cancer.

    The use of radiation therapy in the treatment of gastrointestinal cancer has evolved over the past several decades, in a gradual, stepwise fashion. Since most gastrointestinal cancers are diagnosed at a locally advanced stage, coupled with the inherent sensitivity of most parts of the gastrointestin Issues in Oncology Palliative Care. Issues in Oncology Lung Cancer. At that time, a cancer diagnosis was almost always fatal and was rarely discussed in public. Managing older-aged cancer patients represents one of the major challenges to our health-care system.

    Caring for older cancer patients, with their frequent multiple morbidities and a variable health status, requires special integration of an oncologic and geriatric approach. Moreover, our aging popu Disparities of care that result in poorer outcomes among certain populations have long been an issue addressed by the cancer community and its major organizations such as ASCO. While ethnicity and race play key roles in this ongoing debate over equitable allocation of our precious health-care resour A variety of studies, including one published this past year in the Journal of Clinical Oncology,1 have showed that clinicians who care for seriously ill patients are at high risk for diminished personal well-being, including high rates of burnout; moral distress, defined as the inability to act in Skin Cancer Breast Cancer.

    Recent research1 conducted by Robert H. Pierce, MD, and his colleagues investigating why PD-1 programmed cell death protein 1 inhibitors result in remarkably durable clinical remissions in some patients with melanoma, whereas others reap a short-term benefit or no benefit at all is showing that re Each year in the United States, about 55, people will be diagnosed with head and neck cancer, and of them, about 12, will die of the disease. Although advances have been made in the treatment of head and neck cancer, this disease remains persistently problematic, due, in part, to the complex a As research in transplantation and other promising areas accelerates, we are on the verge of breaking new clinical boundaries in bloo Two years ago, ASCO collaborated with the American Academy of Hospice and Palliative Medicine to develop the Virtual Learning Collaborative, a virtual quality improvement program intended to address the complex care needs of patients with advanced cancer and the care quality for all patients with ma Treatment of advanced bladder cancer continues to prove challenging, and therapies that offer long-term survival remain elusive.

    In an oncology health-care system that is increasingly changing its delivery and payment models, how do busy oncologists successfully bridge the transition from a volume- to value-based, patient-centric model? This, and other topics on value fueled a robust discussion at the Association of Community Epithelioid hemangioendothelioma is a rare and devastating vascular sarcoma that affects between and people, mostly young adults, each year in the United States. The cancer may arise as a solitary lesion but more commonly presents with metastatic involvement, usually in the liver and lungs.

    Colorectal Cancer. Despite advances in detection and treatment, colorectal cancer remains the third deadliest cancer among men and women in the United States. To get a better understanding of the current state of this disease and what lies ahead, The ASCO Post recently spoke with colorectal cancer expert John L. Benjamin O. Anderson about the conceptual framework of the risk-stratificatio The process of identifying a promising molecule and moving it from the laboratory through the highly complex series of clinical trials necessary to garner U.

    Food and Drug Administration FDA approval is a costly scientific gauntlet during which many new agents fail. New trial design, pharmacolog In the book, Dr. Gawande critiques the American medi Although cancer rehabilitation has been a part of oncology clinical practice for several decades, it has largely gone unrecognized as an integral part of palliative medicine and survivorship care. Now, the role of physical medicine and rehabilitation in oncology care may increase as patients with ca Fatigue is such a common—and ongoing—problem among cancer survivors, last spring, ASCO published a clinical practice guideline1 to address screening, assessment, and treatment approaches for the management of fatigue after patients have completed treatment.

    Among the strategies included in the guide Palliative care expert Diane E. Under her leadership, the number of palliative care programs in the United St The Harvard Global Equity Initiative is a research program at Harvard University that is dedicated to promoting equitable global development, with a strong emphasis on health-care issues.

    This initiative brings together scholars, policymakers, advocates, and practitioners from around the world to ad On December 3, , Robert S. Each year, about 70, adolescents and young adults AYAs are diagnosed with cancer in the United States, almost six times the number of cases diagnosed in children up to 14 years of age. While overall cancer survival rates continue to rise—according to the American Cancer Society, there are curre A 4-year study1 involving patients with advanced stages of lung, gastrointestinal, genitourinary, breast, and gynecologic cancers has found that providing early outpatient palliative care vs standard oncology care alone improved quality of life and patient satisfaction.

    The study participants re Advances in science and medicine have led to humans living longer than at any other time in history. Adenocarcinoma of the pancreas is the fourth leading cause of cancer death in men and women in the United States. This year, about 46, people in this country will be diagnosed with pancreatic cancer, and more than 39, will die of the disease.

    Studies show that all cancers and related treatments have the potential to affect sexuality and sexual function. Surgery, chemotherapy, hormonal therapy, bone marrow transplantation, and radiation therapy can physically impact sexual health in myriad ways, including vaginal dryness, dyspareunia, and The report argues that the U. Last fall, Richard R. It is a highly treatable disease, usually curable, that most often develops in young and middle-aged men. Despite the success in testicular cancer, there are still clinical challenges ranging from staging to optimum therapeutic approaches The goal of the research effort was to develop methods to accurately detect ovarian cancer while it was still confined to th Each day, millions of patients with cancer around the world suffer unrelieved pain because they are denied morphine, the gold standard of cancer pain control.

    The World Health Organization has called access to morphine a human rights issue. Not surprisingly, the crisis in unrelieved cancer pain is a In , about 15, people in the United States will be diagnosed with some form of sarcoma, and of those, approximately 5, adults and children are expected to die of the disease.

    Sarcomas are a heterogeneous group of mesenchymal malignancies that have historically been difficult to diagnose an While the development of mentorship relationships is critical in launching and nurturing the academic careers of young investigators, it is also an essential component for continued success throughout their careers, according to Jennifer R.

    Brown, MD, PhD.

    Research findings and theoretical concepts

    In announcing the awards, Charles W. Eleven days before Patricia J. While the diagnosis was shocking, Ms. Goldsmith said it gave her a unique perspective on what it means to have this serious disease and a gre Rauch, MD, Foundi Tests in development to detect circulating tumor cells that escape from solid tumors and travel through the blood, spreading cancer to new sites, may serve as an alternative to conventional tissue biopsy for early cancer diagnosis and gene-expression analysis over the next decade.

    According to Massi Kenneth J. Pienta, MD, and his colleagues at Johns Hopkins Medicine in Baltimore are using the principles of evolutionary game theory to learn how cancer cells cooperate within a tumor to gather energy and metastasize. Game theory, the mathematic study of strategic decision-making that is commonly u With the emergence of molecular diagnostics and new therapeutics, the treatment of acute myeloid leukemia AML is entering a new era.

    Hugo F. Significant weight loss, cachexia, and being bedbound signal that a cancer patient is dying. However, identifying the specific signs that give physicians the ability to predict death is not well described in the literature. To better understand why predicting death is an important part of the care c Thomas P.

    A year prostate cancer survivor and only child, Mr. Over the past several decades, the role of postchemotherapy surgery for advanced testicular cancer has evolved with regard to patient selection, surgical planning, lymph node dissection, and surgical technique. One of the most important cancer survivorship issues is the transition from oncologist to the primary care setting.

    With a growing population of cancer survivors, patients need to feel secure about their primary care provider having the tools to address their special needs. To shed light on this imp Activating the immune system for therapeutic benefit in cancer patients has long been a goal in the scientific community. After decades of disappointment, this intriguing approach has come to the forefront of cancer research, showing promising results in several malignancies.

    To keep abreast of this Advances in cancer treatment have led to increasing numbers of long-term survivors, bringing greater attention to the needs of this growing population. Female cancer patients often experience difficult adjustments related to sexual health and intimacy. To better understand the complexity of this imp In general, he maintained that the overall and complete response rates a Carmen J.


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    8. Despite promising new agents and therapeutic approaches, 5-year lung cancer survival rates have lagged far behind those of most other malignancies. To shed light on some of the important issues facing lung cancer experts, The ASCO Post recently spoke with internationally recognized lung cancer resea Despite advances in cancer screening and in more effective therapies to treat the disease, which have led to improved outcomes and increased survival rates for millions of people with cancer, not every American is reaping the benefits of these advances. Disparities in health-care access, quality of James P.

      For the past 40 years the story of breast cancer surgery in general, and for the past 20 years the management of the axilla in particular, has been one of increasing conservatism. I would like to congratulate Corley and his colleagues for their seminal work on the association between adenoma detection rate and risk of colorectal cancer, advanced colorectal cancer, and colorectal cancer mortality. Patrick M. Boland, MD, and Michael J.

      Gray, MD, AM, a medical oncologist at Dana-Farber Cancer Institute, Boston, and colleagues presented one of the first studies evaluating how academic oncologists perceive the incorporation of a nove A very pleasant year-old woman was referred to my clinic with biopsy-proven liver metastasis from primary colon cancer.

      WCC Programme by UICC - Issuu

      She was initially diagnosed with colon cancer, which was resected, and she then received chemotherapy. A suspicious liver lesion was biopsied in the adjuvant setting, which conf In the clinical array of brain tumors, glioblastoma is the most difficult to treat, and despite decades of research and the advent of new therapies, patients with glioblastoma continue to have a very poor prognosis.

      Leading brain tumor experts at the recent 25th Annual Cancer Progress Conference in Armando E.

      Research findings and theoretical concepts

      The updated guideline, recently publis Bruce G. The large numbers of patients and long-term follow-up i For young adults diagnosed with cancer, coping with the aftermath of the disease can be especially daunting. Although all cancer survivors share some common concerns and distress, for young adults grappling with body image, sexuality, peer pressure, dating, marriage, family planning, education, and Over the past several decades, the convergence of scientific discovery, technology, and therapeutic developments has created an unparalleled opportunity to integrate our growing knowledge of genomics into the clinical practice of oncology.

      To shed light on the current state and future of genomics-dr Thomas A. Significant progress has been made in local-regional and systemic treatments of breast cancer. Most patients currently diagnosed with breast cancer in the United States are diagnosed with early-stage disease and achieve excellent outcomes with breast-conservation therapy. Indeed, outcomes have sign In , the Billings Clinic Cancer Center in Billings, Montana, became one of 15 community-based oncology centers nationwide to receive funding from the National Cancer Institute NCI to expand programs for clinical trials, health-care disparities outreach, survivorship and palliative care, multid Last January, ASCO held a leadership summit in Washington, DC, with representatives from the pharmaceutical industry, insurance payers, patient advocates, and physicians to address the skyrocketing costs of new drugs and technologies used in the diagnosis and treatment of cancer.

      Although costs are Lymphoma Geriatric Oncology. Zelenetz, MD, PhD, fielded questions from oncologists. The ASCO Post was there to capture his recommendations for a common clinical scenario—treating the eld Howdeshell, PhD, and Michael D. Shelby, PhD, discuss a recently completed monograph that reviews the published data on pr I have spent my career working with urologists.

      Over a long period of time, I have concluded that they are fine and interesting people who work hard, live well, support interesting hobbies, generally take good care of their families, and are very enjoyable company at parties. The recent discussion Data from trials conducted mostly in the s and s established the paradigm that optimal treatment of rectal cancer requires a combination of radiation therapy, chemotherapy, and surgery. DePinho, MD, announced his plans to launch the Moon Shots Program, the most ambitious endeavor undertaken by the cancer center to dramatically accelerate the pace of reducing canc More than 2 decades ago, Deane L.

      Wolcott, MD, helped develop comprehensive patient-centered psycho-oncology care in cancer centers across the country. Today, many aspects of that patient-centered care, including psychiatric, dietary, pain management, cancer rehabilitation medicine, survivorship, an In January, Eric S. Lander, PhD, Director of the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, and his colleagues published the results from their landmark study,1 which explored the feasibility of creating a comprehensive catalog of cancer genes.

      The researchers collected and anal Integrative Oncology. When Barrie R. Cassileth, MS, PhD, began researching complementary medicine and its potential for use in oncology care over 30 years ago, not much was known about the importance of complementary therapies for the well-being of patients with cancer. She chose to conduct her doctoral dissertation rese Is pursuing a Master of Business Administration MBA degree a good idea for ambitious surgical oncologists who want to advance their careers? Baselga was formal discussant He alluded to all the factors that complicate assays of PD-L1: the disparate nature of the assays themselves, the David M.

      Ward and colleagues report further co Cannistra, MD, of Beth Israel Deaconess Medical Center, Boston, considered the implications of the benefits observed in the trial and limitations in interpret For much of her career in oncology, Teresa A. Gilewski, MD, has sought to bridge the science of medicine with the humanistic aspect of care.

      We continue that conversation here with our interview of D Kidney Cancer. Richard J. In this second installment of a two-part report First-Line Therapy Please describe current medical oncology approaches to first-line therapy for metastatic renal cell carcinoma. The current first-line therapy for most patients with good- to intermediate-risk metastatic renal cell carcinoma is a vascular endothelial growth factor VEGF receptor Cancer Immunotherapy What is the role of immunotherapy in the treatment of metastatic renal cell carcinoma?

      The harnessing of the immune system as an effective treatment for cancer was recently selected by the journal Science as the top scientific Breakthrough of the Year for Therese B. Daniel B. If a randomized, controlled trial of therapy for breast cancer was submitted for publication in which 1. The drug being tested was old and ineffective, and 2. Currently, one of the most challenging problems in oncology is to accurately predict whether neoplastic lesions detected by screening tests will progress.

      The focus on developing ever-more sensitive cancer screening tests has produced the clinical dilemma of overdiagnosis. Overdiagnosis occurs when Colorectal cancer is a common malignancy that will impact 1. Ronald C. Men with newly diagnosed localized prostate cancer face a decision between prostatectomy and radiotherapy, treatments deemed similarly effective but with well-established trade-offs in terms of treatment-related morbidity.

      Numerous clinical trials and other prospective studies, from both academic an Kyle O. Rove, MD, Ty T. The recent study by Nam et al in The Lancet Oncology—reviewed in this issue of The ASCO Post—provides a fresh perspective on complications other than incontinence or erectile dysfunction that commonly arise after primary treatment of localized prostate cancer. Last fall, Kirsten K. Ness, PhD, published her study1 on the prevalence of frailty as a sign of accelerated aging in adult survivors of childhood cancer, and the results are startling.

      Among the 1, participants in the study, the prevalence of prefrailty was In , Jennifer S. Temel, MD, published her landmark study in The New England Journal of Medicine showing that the introduction of palliative care early after a diagnosis of metastatic non—small cell lung cancer, along with cancer therapy, not only provided patients with a better quality of life b The A Although cancer survival rates among pediatric and older adult patients continue to rise, survival rates for adolescents and young adults AYAs , defined by the National Cancer Institute as those between the ages of 15 and 39, have remained stagnant for decades.

      In breast cancer especially, AYAs fac Victor G.

      Looking for other ways to read this?

      The goal of effective adjuvant therapy is to increase overall survival. It has been suggested cynically that all we need to accomplish, actually, is to delay recurrence until after the time the patients die from another cause. CoMMpass will follow 1, newly diagnosed pati Oncology is a demanding field that requires special qualities to care for very sick patients, many of whom will die prematurely of their disease. Research indicates that years of facing life-and-death decisions in the clinic can be associated with oncology burnout syndrome, which effects physician q Neal J.

      Rebecca A. There is, however, a trend to modest benefit in women older than 55, which is consistent with statistically significant ben Idelalisib is being studied in three ongoing registration trials. Christopher A. Neoplasms originating from skin keratinocytes are increasing in frequency in the United States and include a spectrum of diseases culminating in the development of invasive cutaneous squamous cell carcinoma.

      Although most cases of cutaneous squamous cell carcinoma can be treated conservatively with In , David B. The purpose of the clinical tr While some patients can be managed easily, others are challenging, said Eric P. He will also assume directorship of the comprehensive cancer institute, with While the last 15 years have brought unprecedented advances in oncology drug development, the next 10 years promise to usher in even greater opportunities to realize the goal of precision medicine in the treatment of cancer, providing patients with more effective care and better outcomes.

      We have a dedicated site for Germany. In between there has been a continuous exchange of ideas, suggestions, advice and material for inclusion. Nevertheless, as chairman I should be remiss if I did not acknowledge the Committee's indebtedness to Mr. GOOD STADT, formerly of the University of Manchester, who worked with me in Manchester and undertook the painstaking search of sources of published information and compiled the draft on which this monograph is based. If there are omissions from the bibliography, it is not for want of industry in seeking them out: our difficulty has been to obtain original material from certain sources.

      We hope that the material assembled here will both offer useful guidance to those engaged in public education about cancer and provide a baseline from which future research in this neglected field may stem. Members: Dr F. JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser.

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